Medscape - Diabetes type 2-specific dosing for Glucophage, Glucophage XR (metformin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation. Detailed Metformin dosage information for adults and children. Includes dosages for Diabetes Type 2; plus renal, liver and dialysis adjustments. Metformin is usually taken with meals to help reduce stomach side effects like nausea and diarrhea. Immediate-release metformin is typically taken twice daily with breakfast and dinner, while extended-release metformin is usually taken once daily with the evening meal. This article describes the dosages of metformin, as well as its strengths and how to take it. When taking metformin, always follow the dosage prescribed by your doctor. Learn the safe starting dose, how to titrate, max daily limit, and cost-saving tips for metformin in type 2 diabetes and off-label weight control. Metformin alone: At first, 5 milliliters (mL) two times a day, or 8.5 mL once a day with meals. Your doctor may adjust your dose if needed until your blood sugar is controlled. Our comprehensive metformin dosage guide and chart breaks down starting doses, maximum limits, and timing recommendations for both immediate-release and extended-release formulations. Typically, metformin treatment starts with a lower dose, such as 500 milligrams (mg) twice daily or 850 mg once daily. The exact dosage is tailored based on individual health factors under the guidance of a healthcare professional. For adults, the daily metformin dosage should not exceed 2,550 mg. Metformin dosage guide covering starting doses, maximum daily doses, extended-release dosing, kidney function, and dose adjustments. Metformin is a diabetes medication that helps control blood sugar levels. Here’s how to dose metformin, how to make adjustments, and potential risk factors for adults.